Kim Vopni (00:01.516)
Welcome to the podcast, Isaac. I am excited to have you and talk about something that we've kind of the overall topic I've had on the podcast before overactive bladder and bladder health. We talk about it in many different angles, but you are working with a company. You have designed an incredible product that people can use at home, which is leveraging the therapy called PTNS or percutaneous tibial nerve stimulation.
And I am excited to jump into this topic a little more deeply with you. If you could start out by telling us a little who you are, what led you to this field, first of all, and to creating the amazing product that you have.
Isaac Oppenheim (00:45.244)
Thank you so much, Kim. So yeah, I'm very happy to share a little bit about my background. My background is in the world of textile. And so I work for a factory that made basically all the underwear and undergarment products that you would find at the mall. This factory that I worked for were prime vendors for Victoria's Secret and Nike and Lululemon, Adidas and...
involved in making bra straps and underwear, elastic, designing some of the newer bras. And so what we really learned and understood was anatomy and physiology. And I took that knowledge and
the experience of the factory and we designed the first alternative for women or the ability for women to use a polar halter effectively. Back in the time men were running around with the straps around their chest and women weren't able to do that because their bra was in the way and Adidas came and asked if we could help them embed into the bra, into the sports bra.
the sensors required. of course this was before anybody could imagine that an Apple watch would do all of this, but I'm sharing ancient history here. And so I managed to become the world leader in washable, wearable, conductive elastic wiring, which is very important for people who need it and most people don't. But...
Kim Vopni (02:10.796)
Yeah.
Isaac Oppenheim (02:29.148)
In a personal experience or through my grandfather actually, I came to bump into the problem of overactive bladder and the treatment options that he had available at age 93 were nonexistent due to his age, due to the medications that he was taking, due to his mobility issues. His doctors recommended he buy diapers and...
I value my grandfather so much and respect him, respected him and loved him and that just wasn't a solution for me. That was not the answer. I'm blessed my father-in-law went to Yale Medical School and he felt my pain and said, look.
I'm willing to help you review literature. willing to help connect you with the people I went to medical school with. If we can find something that could help, maybe can help other people. And we discovered that it was not just my grandfather suffering from overactive bladder. It was basically what I of discovered is that probably more people over the age of 50 need a Zydeco control sock than need Coca-Cola.
Kim Vopni (03:41.806)
you
Isaac Oppenheim (03:41.884)
And the nice thing and the good thing about overactive bladder is that it's never killed anybody, but it really kills people's lifestyle. It kills people's ability to engage. It leads to depression. leads to diminished quality of life. People stop having their grandkids over, going out for coffee, exercising, whatever it is.
And that's something that I'm really proud of, having the opportunity and the ability to help people grow and become involved and able to restore their quality of life. Because it is a quality of life issue, and for the people that we love most, which are your listeners, right?
Kim Vopni (04:24.642)
Yeah. Yeah. Amazing. That's very cool. I like that. There's always some sort of most people who I talked to on this podcast have some sort of, you know, pain to purpose or whether it was their own or somebody within their family and, and it's powerful motivators to, make change. And thankfully I see a lot of innovation in the space. So you, mentioned the product, the, company's Ida, the product is the Zyda.
control sock. So it's a wearable as you were talking about you're in the wearable technology space. And if you can well, let's first talk a little bit about you know, overactive bladder. You've mentioned that's what your grandfather was suffering with millions of people do suffer with this. Tell us like from from a high level what is overactive bladder? What are the causes and then we're going to get into the technology side of things and and how your product can help.
Isaac Oppenheim (05:17.126)
Sure, so I think that overactive bladder can best be described as the brain sending the signal to the bladder to empty when it isn't full. So the clinical definition of somebody who suffers from overactive bladder is somebody who goes to the bathroom more than nine times a day. They suffer from, call it urinary frequency.
The other category is urinary urge, urinary urge meaning feeling the desperate need to go to the bathroom. Sometimes people do not make it to the bathroom and they experience incontinence as a result of that.
urinary urge. So the technology of neuromodulation, which Zyda did not invent, has been around for about 40 years. It was invented back in the late 1970s at Yale Medical School. And there are implants available today that you can have put in your lower back, in your leg.
Or there are percutaneous delivery systems where they use a needle to access the nervous system to deliver electric signals, which again reprogram the brain to stop sending the signal to go to the bathroom when your bladder's not full. And that is what our SOC does, what our SOC really does. The technology is taking our knowledge of men's and particularly women's bodies.
We were prime vendors at Victoria's Secret and particularly on the women's side. And so being able to get people to wear a sock that finds the tibial nerve, which is the critical component for successful delivery of neuromodulation, we're able to do that consistently and repeatedly across the body shapes and sizes.
Isaac Oppenheim (07:20.076)
And so a patient puts on a sock, is completely a normal textile sock, like you would wear, except that it has electronics embedded in it. If you can align your toe in your heel and open up your car using your key fob, then you can use this device. I designed it to be that easy. It's extremely complicated, but...
I designed it for my grandfather, right? He was 96 when we were getting towards the, when we were engaged with the FDA. And I recognize it just had to be very, very simple in order for my goal, him, people in that age, even in that age category, to be able to use the device, to be able to, to get the benefit of this treatment that otherwise they don't have access to. What we offer at Zyda is access to care.
I would say that it is gospel that neuromodulation works and can benefit patients who have overactive bladder. What we're just doing is making it more accessible. That's about the technology and thought science behind it.
Kim Vopni (08:30.274)
What is it about the tibial nerve, you mentioned that that's the critical component. How does the tibial nerve influence that mind, body, the bladder connection with the brain?
Isaac Oppenheim (08:45.148)
So there was once a song when I was in elementary school. It involved the foot bone being connected to the leg bone being connected to the... So basically you have the wiring of the body, the nervous system runs from the leg and that same nerve that goes from the ankle also has a connection point at the bladder. And so we're able to access the nervous system.
Kim Vopni (08:50.574)
I remember the song.
Isaac Oppenheim (09:12.84)
and influence the connection between both the bladder and the brain using that access point. The nerve has a relatively close access point at the ankle and that's why we're using the ankle.
Kim Vopni (09:30.616)
Yeah. And you were mentioning a few different types. So the kind of standard PTNS treatment is almost like acupuncture needles and somebody would go in for an in-office visit. They would use the needles around the ankle and hook up electrodes that essentially are going in and influencing the nervous system, specifically the tabular nervous wall, correct?
Isaac Oppenheim (09:55.901)
Yeah, correct. So percutaneous means that that's below the skin. They're using acupuncture like needles. I think that what we learned during COVID was that a surprisingly large amount of people have needle phobia.
That has prevented access. That was not something that I was aware of in my development of the product, but I've bumped into and kind of seen how many people would like to have access to percutaneous treatment, but due to fear of needles, don't feel comfortable doing that, particularly in something that they consider to be elective. And the other thing is the number of women that over...
overactive bladder effects. Like I mentioned, I got into this for my grandfather, but really discovered that this predominantly impacts women, and particularly women over the age of 50.
Kim Vopni (10:49.166)
Right. So with your so you know the philosophy of PTNS and specifically now to yours, you have eliminated the barrier of in-office visits, the needle phobia. You mentioned it's a sock you put on and that has the technology embedded into it. And so I'm assuming the person puts it on there's some sort of a press the button and it starts. What is involved with
like the treatment session. So how long would somebody wear the sock for? How often would they turn it on or off? And is this something that would be a period of time treatment or is this something that they would be kind of ongoing two to three sessions a year for a week, sorry, for the rest of their life?
Isaac Oppenheim (11:35.997)
Sure, so the most important thing about using any medical device or any pharmaceutical, right, is that if you don't take it, you don't use it, it never works. And so creating a schedule in treatment is, in my opinion, I'm not a doctor, I'm not authorized to tell people how to do it, but find something that works for you. What we recommend and what the FDA has approved the use for is to use it once a week. Once a week for 30 minutes.
doctors, physicians can create alternative protocols if that's what they feel would work best for the patient. I believe that using the device once a week for 30 minutes.
you know, was proven and demonstrated to be effective in the clinical trial that we ran. And also, it's something that likely requires continued maintenance basically for the rest of a patient's life. Being able to say, hey, I can allocate 30 minutes a week on Sunday evenings every week is something that will provide benefit in the long term. You know, if you were to do it more frequently for a shorter period, maybe you'd get that benefit, maybe you wouldn't.
but you probably forget at some point because you're on vacation because, and finding that just regularity of use is something that I believe in. This is not just about our product. It's about any form of treatment. just have to find and be consistent in using them as you're, guided by your doctor.
Kim Vopni (13:05.762)
Yeah. Overactive bladder is the main component. Could this help somebody who also had anal incontinence, anal urgency or frequency?
Isaac Oppenheim (13:21.082)
So I believe that there have been a number of studies that have demonstrated such benefit. To date, we have not investigated anal incontinence with our product. we haven't investigated it at all. And the FDA has not cleared the product for that use. If that's something that your doctor felt could be of benefit, that's something worth discussing with them.
Kim Vopni (13:48.463)
Yeah, yeah, okay. And you mentioned your own clinical trial and there was also subsequent study. So can you tell us a little bit about the clinical trial and study and what, like, what was, who was the population involved? How long was the study time? And like, how long would it take somebody to notice change?
Isaac Oppenheim (14:09.436)
Sure, so our device has a 80 % clinical success rate. We ran a double blind placebo or sham controlled trial out of a clinic in Miami, Florida. There were 40 patients who were enrolled. As I mentioned, 80 % of them
were successful in getting clinical benefit. The clinical benefit provided on average was about a 70 % reduction in urgency. And that kind of meets.
that is equivalent to percutaneous treatment. And not just the FDA agreed with that, even most insurers have agreed with that and are covering our device similarly to either percutaneous or even prefer it to percutaneous treatment. At the end of the day, our device is cheaper than to the healthcare system than percutaneous treatment.
And so it's something that, as I mentioned, it's something that patients should use once a week for 30 minutes. If they've got benefit after 12 weeks, which is the initial treatment period, then they should consult with their doctor and potentially continue using it indefinitely. Most patients begin to see clinical benefit after six weeks. Some people report benefit immediately. But the general...
The general population typically sees a response about six weeks in. And even if you don't, it's worthwhile to get into at least that 12 weeks before going back to your doctor and discussing potential further treatment options.
Kim Vopni (15:53.977)
Yeah, yeah. So what is the cost? Is this available in the US only and do you need a prescription for it?
Isaac Oppenheim (16:03.324)
Sure, so it is a prescription medical device. It is available currently in the United States. I believe that in Canada there are options to receive it as a patient pay product. In the United States, the majority of our patients would like their insurers to pay. Like I mentioned, most insurers, including Medicare, are paying for the device thus far.
95 % of our Medicare patients have a secondary coverage and therefore the device costs them nothing. Just like if they were to go in and get percutaneous treatment. For patients who have Medicare Advantage plans, I would say that it...
It varies just because Medicare Advantage plans themselves vary so much. We have an amazing team. Our goal is to make the device available at no cost to patients. Are we able to do that for everybody? Unfortunately not, but that's my goal. My goal in inventing this device was to help patients.
I am not the one on the phone with every single patient, but I hope that my vision, my philosophy, my passion is something that all of our team members incorporate and work with patients in order to help them improve their quality of life. And this is something that, you know, I'll say this kind of has a, just a general philosophy. we, when we running our clinical trial,
Everything was going really well and the patients were so happy. And I remember I just got this phone call from the secretary who was in charge of contacting the patients. She was like, I don't know what happened. All of a sudden I got two patients. They called me and they said that the device is making them so much worse. They've been saying that it's helped them so much. They're no longer feel like they have overactive bladder or it's improved their lives tremendously. But since last night, they've both been going and running to the bathroom constantly.
Isaac Oppenheim (18:05.532)
I said, oh my gosh, I don't know. I'm not a doctor. I don't know what to do. Get the doctor. What's wrong when we got our, you know, I'm calling our doctor and the clinical, the primary investigator of the clinical trial. And we said, what's wrong with these patients? What's wrong with the device? And both doctors said, well, do they have a UTI? Did anybody check? And then it was like, oh, UTI, that could be it. And both of them had a UTI. And you know, as far as the patients were concerned.
Kim Vopni (18:24.215)
You
Isaac Oppenheim (18:33.808)
the device was was causing their problems. And they would have stopped taking, if it was a pill, they would have stopped whatever form of treatment they were engaging in because...
in their mind the obvious cause was our device. this is something that, know, things just happened in our clinical trial. It happens a couple of times a week that people blame our product on caught their no longer improved symptoms. And it's really, they've got a UTI and it's really important to have somebody to lean on. And at Zyda, we make our patient advocates available, you know.
I would like to say 24 or seven as much as possible. And they're calling and following up with patients in order to dispell false beliefs like my UTI is not what's causing my change in progress.
Kim Vopni (19:26.574)
Yeah, yeah. So if somebody then in Canada, right now it's not available, a Canadian couldn't go to your website and purchase it directly from the website, is that correct?
Isaac Oppenheim (19:38.813)
So a Canadian can get a prescription and we do have Canadians who are going to to coming to us and getting the device. It is a prescription device also in Canada. I do not believe that it's available called under national health in Canada. No, it is not available under national health in Canada, but it is available to patients, you know, through their, you know.
Kim Vopni (19:55.342)
Probably not.
Isaac Oppenheim (20:02.886)
through the regulatory process. So if a patient wants it, they can get it, but it is not covered by the National Health Care System.
Kim Vopni (20:10.412)
Yeah, and what was the cost of them?
Isaac Oppenheim (20:13.2)
So the price for what I recommend, right? I'm here to try and help patients and try and make it as affordable as possible. So for patients who do not have insurance or patients who live in Canada, we make the product available as a rental and they can rent it for...
Kim Vopni (20:33.688)
Mm-hmm.
Isaac Oppenheim (20:36.944)
the first 12 weeks for $549 all in everything. If they have benefit and they wanna continue using it, it's $70 per month going forward. If it's stop doesn't work for them, then that's fine too. It's a rental and the goal is not to get people to buy things that are not necessarily gonna help them. We do have a purchase option, but I don't recommend anybody buy it unless...
Kim Vopni (20:52.536)
Yep, yep.
Isaac Oppenheim (21:03.652)
unless they're coming to us because they know that PTNS works for us. For example, we've had a large number and the initial prescriptions we actually received were from patients who had MS, Parkinson's or ALS that had been getting a lot of benefit from percutaneous treatment and their insurer said, we're not gonna keep paying for this. Or they were no longer able to travel to get the PTNS and they said, look, I just wanna buy it.
Kim Vopni (21:25.475)
Mm-hmm.
Isaac Oppenheim (21:33.27)
I know that this works, but my insurer or my mobility is enabling me to continue. So in that case, fine. But somebody just off the street, I want to try and help improve my life. We're not looking to take money from people in a way that is not beneficial to them.
Kim Vopni (21:33.272)
Right.
Kim Vopni (21:49.465)
Yeah. So I'm confused then with if it's something that's rental. is it a technology that you put into any pair of sock? how would somebody rent a sock? I guess this is what.
Isaac Oppenheim (22:02.972)
Sure, the sock itself is called a supply. You're renting, it the treatment, where the sock itself is a sock like any other sock. It's not something, we're not gonna take it back and reuse it. We do need to get it back, it, for regulatory purposes and what have you, but we do not reuse socks. The electronic device, which is the size of my...
finger is something that we do get back and we do refurbish and resupply and that is called the real rental item. The socket itself and the batteries and the gel that go along with it are our accessories.
Kim Vopni (22:48.91)
And so if somebody has, whether they've purchased it, been supplied through their insurance, or this is something that's in a rental, is it washable or can the person take the technology out and put it back in if they do need to wash it, or how does the care at home work?
Isaac Oppenheim (23:04.582)
Sure. So the electronic component here uses magnetic snaps and attaches to the sock. It's pretty easy.
Kim Vopni (23:15.054)
It's like a tiny little key fob, as you mentioned, for your car.
Isaac Oppenheim (23:17.02)
It's a tiny key fob and uses similar snaps to those that might appear on a purse. The sock itself can be washed, cold water, along with everything else that you're doing in your colds, and should be air dried.
Kim Vopni (23:35.682)
and then you would just stick.
Isaac Oppenheim (23:35.854)
and it can be washed 30, 40 times. Like I mentioned, we come from the world of sportswear and we know how to make things washable. The electronics should not be put in the wash.
Kim Vopni (23:44.079)
Yeah. Yeah. So you take the key fob off, you wash the sock, and then you put your key fob back on after it's dried. Got it. Perfect. That's very, very cool. what else other questions do I have here? So the population, what is appealing to me about this in so many ways is the accessibility. As you mentioned, there are some people who
Isaac Oppenheim (23:50.165)
Yeah.
Kim Vopni (24:12.27)
maybe geographically can't get somewhere, maybe mobility wise they can't get somewhere. So this is a very easy, something people could, if they can put on a sock themselves or if they have a care provider who could put on the sock for them, they can seek benefit. What sort of, I guess you talked about patient advocacy, what other information or education potentially would be shared or if any to the patient's
Do they is there any sort of screening to say have you addressed this have you are you using this product? Have you tried pelvic or muscle training? Like what other things that are maybe supporting before somebody may feel like this is the only option available for them?
Isaac Oppenheim (24:54.428)
So A, I don't believe that this is the only option. think that, I don't believe that our product is the product that will save the world. It is a combination of products that will probably save the world. Meaning 25 % of patients who have used our SOC in our clinical trial reported no longer met the criteria of having overactive bladder.
That doesn't mean that they're actually cured. It just means that they can keep using the sock and maintain that benefit of not having the symptoms of overactive bladder. The majority of our patients are patients who have more severe overactive bladder than that. And a 70 % improvement is great, right? But if I was the patient, right, I would want 100 % symptom improvement.
And I believe that getting there is something that requires a combination of...
pelvic floor therapy and behavioral education. And potentially in the future or in cooperation with your doctor, maybe using other medications. A lot of women also have stress incontinence. I can't cure your stress incontinence. You need to do your Kegels. You may need some sort of surgical treatment. I want to help you as a holistic person. As a holistic person, our team provides
weekly educational materials by email. We're calling patients, we're sending texts in order to try and help everybody in their individual way to improve and get the maximum improvement that they can. That is my goal. And for good or for bad, we have an 80 % success rate, right? Which is great.
Isaac Oppenheim (26:45.084)
But that means that I know ahead of time that 20 % of the people who use my product are not gonna get the benefit that they want from using it. And I want you to know that you're not getting that benefit. How am I gonna help you know that? By collecting a bladder diary or quality of life survey from you at, before you start using the product, and then 12 weeks in saying, hey, well, amazing, you had an 80 % improvement.
Kim Vopni (26:52.685)
Yeah.
Isaac Oppenheim (27:10.138)
That's great. But okay, maybe you didn't have that improvement that we were hoping for you to have. Great. What are your options? Should you go back to your doctor? Yes, you should go back to your doctor. You should go back to your pelvic floor therapist. you haven't been going to the pelvic floor therapist? Why not?
Kim Vopni (27:24.494)
Yeah.
Isaac Oppenheim (27:26.448)
You know, it's been snowing on it's hard for you to get there, great. know, the problem is that you're having your incontinence when you sneeze. well, maybe we've helped you with your overactive bladder, but you really need to work on your kegels. So.
Kim Vopni (27:44.911)
Yeah. Who, when you think of the 20%, know, unquote 20 % who this isn't necessarily successful for, if we look at overactive bladder, different reasons that can contribute to overactive bladder, who would this not, in the overactive bladder category, who would it potentially not work for?
Isaac Oppenheim (28:07.492)
I think that the people who are on the most, I would call the most severe spectrum are people who it may not work for, most severe meaning patients who are...
that, you know, who are unable to, who have basically no mobility, they are using diapers full time, are probably the people that this is not the greatest product for. Meaning somebody who's a, I would call an active senior, an act, you know, lives an active life, is somebody who is gonna get the most benefit, right? If I'm able to help you get back to work, I'll, we have a patient in San Francisco who called us up and was so excited, she said,
I'm 52, I'm a lawyer, and I live about an hour outside of the city of San Francisco, and basically I stopped going into the office or court, because I couldn't, I kept finding myself squatting on the side of the road on the highway every time I went into the office. And that's not who I am. I'm a serious lawyer. I can't be squatting on the side of the road because
of my bladder. And what I discovered is, using your product allowed me to go back to the office. Does that mean that I want to go into the office and commute every day? No, but that's a separate issue. So, I think that people like that. And it's also people who stop going out to play cards or to go on the boat or...
Kim Vopni (29:34.478)
Yeah.
Isaac Oppenheim (29:47.581)
out for coffee with friends are the people who are most likely to get benefit. Meaning the people who are the more likely in a nursing home are probably the people that are gonna get the least benefit. Though I have to admit that for a family member of mine who was in the nursing home and...
was having issues with the staff coming to change their diaper and change it frequently enough. She was using the Zydeco control sock and it helped. Did it cure the problem? It didn't cure the problem. This family member was over 100 years old.
Kim Vopni (30:32.59)
Mm-hmm, mm-hmm. And you mentioned your grandfather, and I think you said 93, correct? Was it ready in time for him to use it?
Isaac Oppenheim (30:38.534)
Correct.
Unfortunately, you know, it was not, he passed away during COVID. And we got our clearance towards the tail end or from the FDA towards the tail end of COVID. So unfortunately he wasn't able to benefit, but you know, I'm happy that in his memory and as a result of his inspiration, I'm able to help.
many other people because I know that that's something that he valued in his life was helping others. So I'm happy that in his memory and in his merit we're able to do that.
Kim Vopni (31:14.446)
Amazing. When, how long have you actually been available? Like how long have you actually been on the market? How long have people been using your product? Six months, wow.
Isaac Oppenheim (31:22.918)
About six months. We've only been out here about six months and I mentioned that I reached out to you because one of our patients said that she's an avid listener of yours. so that was how I found you. And I appreciate the amazing work that you're doing here and helping people with patients with the whole range of life's issues.
Kim Vopni (31:51.979)
Mm-hmm. Yeah, yeah. It's so much more than, you know, Kegel exercises. And I think people, when they first come into my program, they feel a little bit overwhelmed because they're like, I just came for the exercises, but there's a whole bunch of other things that we cover in there. something I also say is it's like, we...
need. We deserve this information earlier in life, but at least you're getting it now. And also we benefit from a healthcare team, a collaborative approach to
our care and that could involve a zyda sock, could involve pelvic floor physical therapy, the exercises that I provide. It's not just kind of like a one and done thing. I think what you've created is so incredibly innovative, valuable and I think it's gonna change people's lives and this is as you mentioned for men and women, even though you've noticed it's predominantly women who are struggling, but I would think like I...
The times I so many women in my community will say, will this help my husband or my brother in law who is now going through prostate issues? And that's often when bladder challenges show up for men. Yeah, they can have pelvic floor challenges throughout their life as well, but prostate issues seem to be a major trigger for the urinary urgency and frequency. Are you noticing that that is a kind of a common population of your patient group?
Isaac Oppenheim (33:18.224)
So there are definitely, we definitely do have a large group of men. I think that men who are hoping to avoid prostate surgery by using our sock, I'm not sure that we're gonna get you what you want. so, you know, for those who have, for men who have overactive bladder and many of those men who have prostate issues have,
Kim Vopni (33:33.056)
No, no, no. But the people who have maybe like prostate cancer who have issues afterwards, yeah.
Isaac Oppenheim (33:46.813)
of active bladder, we can help them. we, know, for the guys who are hoping to avoid prostate surgery, you know, we're not gonna do that. But for the guys after post-prostate surgery, we can often help. And even before, it definitely can help. But if not, we're not the silver bullet that a lot of these guys are hoping for, I would say.
Kim Vopni (33:54.606)
Not so much.
Kim Vopni (34:06.998)
Yeah, yeah, yeah, fair enough, fair enough. Well, I think what you've created is extraordinary and I'm really glad that whoever it was that reached out to you and you reached out to me that I could learn about this technology. I know it's something that I think a lot of people in my community would be interested in learning more about. The majority of my community is in the United States, so this will be accessible to too many and hopefully it'll become more available. Do you have plans of expanding elsewhere around the world as well?
Isaac Oppenheim (34:35.868)
Yeah, absolutely. We are definitely hoping to expand outside of the United States. think that as we all know, the United States is the leader that Europe certainly looks to the United States and particularly to the Medicare system as being the standard of care. And so as we gain traction in the United States, Europe, Canada, Australia,
Kim Vopni (34:44.526)
Okay.
Kim Vopni (34:50.723)
Mm-hmm.
Isaac Oppenheim (35:02.03)
and Asia in general are places that we're looking to expand to.
Kim Vopni (35:06.094)
Amazing. Where can people find out more, learn more, and potentially have this as a prescription for themselves?
Isaac Oppenheim (35:15.772)
Sure, so if they visit our website, it's Livzida.com. We have the prescription form available there. You can download it and bring it to your doctor. Of course, you can also learn about the technology itself, the product itself. And we do have a hotline that you can call and get as much information from our amazing patient reps who are there to help and are extremely patient.
with our patients.
Kim Vopni (35:44.687)
Yeah, amazing. I just remembered, sorry, one question I forgot to ask when you mentioned the treatment 30 minutes, one time a week, it's, what does it feel like for the patient when they have this sock on it? What is, is it buzzing? Is it a vibration is what is actually stimulating or maybe simulating is not the right word, but in going and interfering maybe with the signaling into the tibial nerve.
Isaac Oppenheim (36:11.484)
Sure. So what does it feel like? I would say the sensation varies. The majority of patients, are guided to turn the device on and it uses a similar, call it interface like an old radio where there's a plus button and a minus button. You are guided to turn up the plus button until you feel, you can depress it.
the plus button until you feel something and then you're guided to turn it down. You can or you should potentially feel your toe flexing, meaning involuntary motion or you sense that your toe wants to move, your big toe wants to move, whether it's moving or not depends. But.
a certain percentage, about 25 % of the people don't feel anything at all, no matter how they turn it up and we guide them to turn up the simulation by depressing the plus button for five seconds. That's at the maximum. And the device often works, works for 80 % of the people who don't feel it also. So sensory perception is not necessarily an indication, but it is certainly something that if you do feel, you should look for that.
that motion or that feeling of your toe trying to flex.
Kim Vopni (37:37.55)
Interesting, cool. Alrighty, well thank you so much again for your work and I'll have the links to your website down below so people can check it out and learn more. And I appreciate very much your time, thank you.
Isaac Oppenheim (37:50.225)
Thank you so much, Kim. I appreciate it and I appreciate your audience. Thank you.
Kim Vopni (37:54.095)
Thank you.
